Nanovaccines to combat virus-related diseasesReview Published on 2023-03-012023-07-10 Journal: Wiley interdisciplinary reviews. Nanomedicine and [Category] COVID19(2023년), [키워드] antigen presenting cells Infectious diseases Nanovaccines targeting lymph nodes. [DOI] 10.1002/wnan.1857 PMC 바로가기 [Article Type] Review
Artificial Cell Membrane Polymersome-Based Intranasal Beta Spike Formulation as a Second Generation Covid-19 VaccineArticle Published on 2022-10-252022-11-15 Journal: ACS Nano [Category] COVID19(2023년), SARS, 변종, 비임상, 진단, [키워드] ACM acute respiratory syndrome adverse effect airway antibodies antibody antigen presenting cells artificial Beta Beta spike C57BL/6 cell membrane clinical symptom clinical trial component conditions coronavirus coronavirus disease COVID-19 CpG cross-neutralizing current delivery of cargo dendritic cells dose doses evaluate evaluated Formulation generate Generation Good hamster hamsters immune responses immunization immunogenic induce Infection initiated interval intranasal mice neutralize neutralizing antibody neutralizing responses New omicron Phase 1 polymersome Practice PROTECT reduction repeated Safety SARS-CoV-2 second serum IgG spike Spike protein Spike-based vaccine Support Toxicity upper respiratory tract Vaccine vaccine. variants viral clearance Viral load virus weight loss wild type [DOI] 10.1021/acsnano.2c06350 PMC 바로가기
New Discovery of Myeloid-Derived Suppressor Cell’s Tale on Viral Infection and COVID-19Immunology Published on 2022-02-032022-10-31 Journal: Frontiers in Immunology [Category] COVID-19, COVID19(2023년), MERS, SARS, [키워드] addition animal model antigen presenting cells Biomarkers Cancer Cell COVID-19 develop Diseases function Genetic Host immune response immune immune evasion immune regulation Immunopathogenesis include induce Inflammatory MDSC Natural killer cells New Numerous Occurrence pathogen Regulation SARS-COV-2 infection significantly Stress suppress suppressor T-cells Therapeutics tissue damage viral infection virus [DOI] 10.3389/fimmu.2022.842535 PMC 바로가기 [Article Type] Immunology
Vaccine Technologies and Platforms for Infectious Diseases: Current Progress, Challenges, and OpportunitiesReview Published on 2021-12-162022-10-28 Journal: Vaccines [Category] COVID-19, [키워드] added antigen presenting cells Bacterial benefit current demonstrated DNA DNA vaccine form immunology inactivated Inactivated vaccine Live attenuated vaccine mechanism mRNA mRNA vaccine next generation vaccines nucleic acid nucleic acid vaccines opportunity peptide platform polysaccharide polysaccharide vaccine populations Progress public health subunit vaccines technology toxoid vaccine Vaccine vaccine platforms vaccine types viral vectored vaccine virus-like particles [DOI] 10.3390/vaccines9121490 PMC 바로가기 [Article Type] Review
Brief report: Tempol, a novel antioxidant, inhibits both activated T cell and antigen presenting cell derived cytokines in-vitro from COVID-19 patientsArticle Published on 2021-10-012023-06-19 Journal: Clinical immunology (Orlando, Fla.) [Category] MERS, SARS, [키워드] antigen presenting cells COVID-19 Cytokines Inflammation T cells Tempol. [DOI] 10.1016/j.clim.2021.108828 PMC 바로가기
Protective heterologous T cell immunity in COVID-19 induced by the trivalent MMR and Tdap vaccine antigens3가 MMR 및 Tdap 백신 항원에 의해 유도된 COVID-19의 보호 이종 T 세포 면역Clinical and Translational Article Published on 2021-08-142022-09-14 Journal: Med (New York, N.Y.) [Category] MERS, SARS, 임상, 진단, 치료기술, 치료법, [키워드] Abstract Activation acute respiratory syndrome Administered Analysis Anti-viral immunity Antibody titers Antigen antigen presenting cells antigens APC assays autologous CD45RA Cell co-cultured Cohort Context Control coronavirus coronavirus disease correlation COVID-19 COVID-19 patient COVID-19 patients COVID-19 vaccination cross-reactive death disease severity Donor driving Effect effective effector memory elicit ELISA ELISPOT ENhance enzyme-linked immunospot epitope feature Features finding flow cytometry foundation funding Heterologous heterologous immunity IFN-γ IL-15 Immunity implicated individual individuals Infection interferon-γ investigated memory memory T cells microbe mitigate MMR nucleocapsid outcomes overlapping Participants Pathogens phenotype promote PROTECT Protective Protein Reactivation recognizing reduced required response risk prediction SARS-CoV-2 SARS-CoV-2 antigen scRNA-seq severe COVID-19 Single-cell RNA sequencing subset supported T cell TCR TCR repertoire transcriptional Transcriptome trivalent uninfected vaccination Vaccine vaccine antigen Vaccines validation study viral infection with mild disease [DOI] 10.1016/j.medj.2021.08.004 PMC 바로가기 [Article Type] Clinical and Translational Article
Hypothesis: Immunotherapy by Selective Convalescent Blood Engineering to Stifle Diseases like COVID-19가설: COVID-19와 같은 질병을 억제하기 위한 선택적 회복기 혈액 공학에 의한 면역 요법Review Published on 2021-08-012022-09-10 Journal: International Journal of Medical Sciences [Category] MERS, SARS, 치료제, [키워드] adaptive anticipated Antigen antigen presenting cells antiviral drug APCS approach arrest Blood blood therapy CD4+ CD8+ Cell convalescent Convalescent Blood COVID-19 current Defense effective Efficiency emergency response Engineering Epidemic highlight Immune cell immune cells Isolation Leukapheresis memory outbreak pandemic pathogen plasma presenting quarantine reducing mortality selective subsequent recovery T memory cells testing protocol therapy transfusion Transfusion therapy treat Treatment vaccination Vaccine Viral viral outbreak WBC [DOI] 10.7150/ijms.46363 PMC 바로가기 [Article Type] Review
Lymphocyte Changes in Severe COVID-19: Delayed Over-Activation of STING?심각한 COVID-19의 림프구 변화: STING의 지연된 과활성화?Review Published on 2020-12-012022-09-11 Journal: Frontiers in Immunology [Category] MERS, SARS, 바이오마커, [키워드] ACE2 activated Activation acute respiratory syndrome affected antigen presenting cell antigen presenting cells Aspirin autophagy B cell B cell response B cells CD147 CD26 CD4+ CD8+ CD8+ T cell cGAMP cGAS change contribute coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 cyclic cytokine cytokine secretion damages Delayed dinucleotide DNA DNA damage early stages Express expressed functional Gain of function Genes Host Human IL-6 immune cells induce infancy Infection inhibit inhibitor interferon IRF3 Last less lymphocyte Lymphocytes lymphopenia main receptor microbial NF-κB pathway Pneumonitis Recognition respiratory responsiveness SARS-CoV-2 severe coronavirus disease severe COVID-19 severe COVID-19 patient severe COVID-19 patients similarity SLC19A1 small molecule Small molecules stimulator STING T and B cell responses T cell T cells TBK1 TCR Th2 transfer triggered Vasculopathy [DOI] 10.3389/fimmu.2020.607069 PMC 바로가기 [Article Type] Review
The Dynamics of the Ferret Immune Response During H7N9 Influenza Virus InfectionImmunology Published on 2020-09-242022-11-01 Journal: Frontiers in Immunology [Category] Coronavirus, MERS, SARS, [키워드] Activation animal model antigen presenting cells antigen-presenting cell CD8 cellular Depletion disease disease severity Dynamics ferret ferrets greater H7N9 Health Host host-pathogen interaction hosts Human human infections immune mechanism Infection Influenza Influenza virus inoculated lymphocyte Lymphoid tissue mammalian mechanism outbreak outcome pandemic progression provide reduced response SARS-CoV-2 sick T cell virus virus strain viruses zoonoses zoonotic [DOI] 10.3389/fimmu.2020.559113 PMC 바로가기 [Article Type] Immunology
MERS-CoV pathogenesis and antiviral efficacy of licensed drugs in human monocyte-derived antigen-presenting cellsResearch Article Published on 2018-03-222022-10-28 Journal: PLoS ONE [Category] Coronavirus, [키워드] addition antigen presenting cell antigen presenting cells antigen-presenting cell antiviral activity Antiviral effect antiviral efficacy antiviral response APC APCS assays cell lines cells chemokine Chloroquine clinical study Compound cytotoxicity dendritic cell determine drug evaluate evaluated Fatality rate highlight Human human monocyte-derived macrophage immature immortalized cell lines Inflammatory cytokine MDM MERS MERS-CoV MERS-CoV infection Middle East Pathogenesis primary cells Proinflammatory cytokine protective immune response public health Replication respiratory syndrome coronavirus robust severe respiratory disease tested therapeutic option Treatment upregulation virulence while [DOI] 10.1371/journal.pone.0194868 PMC 바로가기 [Article Type] Research Article